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pentobarbital will lower the level or outcome of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital improves effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide with CYP2B6 inducers might boost metabolism of ifosfamide to i